Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Stalled Spliceosomes Are a Signal for RNAi-Mediated Genome Defense

Using the yeast Cryptococcus neoformans, we describe a mechanism by which transposons are initially targeted for RNAi-mediated genome defense. We show that intron-containing mRNA precursors template siRNA synthesis. We identify a Spliceosome-Coupled And Nuclear RNAi (SCANR) complex required for siRN...

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Bibliographic Details
Main Authors: Dumesic, Phillip A (Author), Natarajan, Prashanthi (Author), Chen, Changbin (Author), Drinnenberg, Ines A (Author), Schiller, Benjamin J (Author), Thompson, James (Author), Moresco, James J (Author), Yates, John R (Author), Madhani, Hiten D (Author), Bartel, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-15T13:43:44Z.
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