The aneuploidy paradox: costs and benefits of an incorrect karyotype

Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date, aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also a hallmark of cancer, a disease of enhanced proliferative capacity, and aneuploid cells are frequently recove...

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Bibliographic Details
Main Authors: Sheltzer, Jason Meyer (Contributor), Amon, Angelika B. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-06-05T18:31:04Z.
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