Crystallographic snapshots of sulfur insertion by lipoyl synthase
Lipoyl synthase (LipA) catalyzes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octanoyl chain to produce the lipoyl cofactor. To activate its substrate for sulfur insertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry...
| Main Authors: | , , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences (U.S.),
2018-05-01T17:31:52Z.
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| Subjects: | |
| Online Access: | Get fulltext |