Crystallographic snapshots of sulfur insertion by lipoyl synthase

Crystallographic snapshots of sulfur insertion by lipoyl synthase

Lipoyl synthase (LipA) catalyzes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octanoyl chain to produce the lipoyl cofactor. To activate its substrate for sulfur insertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry...

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Bibliographic Details
Main Authors: Lanz, Nicholas D. (Author), Lee, Kyung-Hoon (Author), Booker, Squire J. (Author), McLaughlin, Martin I. (Contributor), Goldman, Peter John (Contributor), Drennan, Catherine L. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2018-05-01T17:31:52Z.
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