Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

Gene expression heterogeneity in the pluripotent state of mouse embryonic stem cells (mESCs) has been increasingly well-characterized. In contrast, exit from pluripotency and lineage commitment have not been studied systematically at the single-cell level. Here we measure the gene expression dynamic...

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Bibliographic Details
Main Authors: Semrau, Stefan (Author), Goldmann, Johanna E. (Author), Soumillon, Magali (Author), Mikkelsen, Tarjei S. (Author), Jaenisch, Rudolf (Contributor), van Oudenaarden, Alexander (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-04-18T14:52:28Z.
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