How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes

How nonuniform contact profiles of T cell receptors modulate thymic selection outcomes

T cell receptors (TCRs) bind foreign or self-peptides attached to major histocompatibility complex (MHC) molecules, and the strength of this interaction determines T cell activation. Optimizing the ability of T cells to recognize a diversity of foreign peptides yet be tolerant of self-peptides is cr...

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Bibliographic Details
Main Authors: Chen, Hanrong (Author), Chakraborty, Arup K (Contributor), Kardar, Mehran (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: American Physical Society, 2018-04-04T20:33:17Z.
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