Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood

Mammalian genomes contain thousands of loci that transcribe long noncoding RNAs (lncRNAs), some of which are known to carry out critical roles in diverse cellular processes through a variety of mechanisms. Although some lncRNA loci encode RNAs that act non-locally (in trans), there is emerging evide...

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Main Authors: Verdine, Vanessa K. (Author), Aguet, Francois (Author), Fulco, Charles P. (Author), Tseng, Yuen-Yi (Author), Boehm, Jesse S. (Author), Joung, Julia (Contributor), Engreitz, Jesse Michael (Contributor), Konermann, Silvana M (Contributor), Gootenberg, Jonathan S (Contributor), Sanjana, Neville E (Contributor), Wright, Jason (Contributor), Yoon, Charles (Contributor), Lander, Eric Steven (Contributor), Zhang, Feng (Contributor), Abudayyeh, Omar O. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Abudayyeh, Omar Osama (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-02-14T14:36:28Z.
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