An Umpolung Approach for the Chemoselective Arylation of Selenocysteine in Unprotected Peptides
Herein we report an umpolung strategy for the bioconjugation of selenocysteine in unprotected peptides. This mild and operationally simple approach takes advantage of the electrophilic character of an oxidized selenocysteine (Se-S bond) to react with a nucleophilic arylboronic acid to provide the ar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2018-01-11T14:59:13Z.
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| Subjects: | |
| Online Access: | Get fulltext |