Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation

Macrocyclic peptides are important therapeutic candidates due to their improved physicochemical properties in comparison to their linear counterparts. Here we detail a method for a divergent macrocyclisation of unprotected peptides by crosslinking two cysteine residues with bis-palladium organometal...

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Bibliographic Details
Main Authors: Reilly, John (Author), Rojas, Anthony Jose (Contributor), Zhang, Chi (Contributor), Vinogradova, Ekaterina V. (Contributor), Buchwald, Nathan (Contributor), Pentelute, Bradley L. (Contributor), Buchwald, Stephen Leffler (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry (RSC), 2018-01-10T15:31:37Z.
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