Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

Striatopallidal dysfunction underlies repetitive behavior in Shank3-deficient model of autism

The postsynaptic scaffolding protein SH3 and multiple ankyrin repeat domains 3 (SHANK3) is critical for the development and function of glutamatergic synapses. Disruption of the SHANK3-encoding gene has been strongly implicated as a monogenic cause of autism, and Shank3 mutant mice show repetitive g...

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Main Authors: Zang, Ying (Author), Lyman, Katherine (Author), Guo, Baolin (Author), Wu, Shengxi (Author), Gerfen, Charles R. (Author), Wang, Wenting (Contributor), Li, Chenchen (Contributor), Chen, Qian (Contributor), Van der Goes, Marie-Sophie (Contributor), Hawrot, James (Contributor), Yao, Annie (Contributor), Gao, Xian (Contributor), Lu, Congyi (Contributor), Zhang, Qiangge (Contributor), Wang, Dongqing (Contributor), Fu, Zhanyan (Contributor), Feng, Guoping (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: American Society for Clinical Investigation, 2017-11-20T19:22:56Z.
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