Evaluation of (acyloxy)alkyl ester linkers for antibiotic release from siderophore-antibiotic conjugates
The syntheses of five ciprofloxacin-modified (acyloxyl)alkyl esters and two siderophore-ciprofloxacin conjugates based on enterobactin that harbor such hydrolyzable linkages are reported. The hydrolytic stabilities of ciprofloxacin-modified (acyloxy)alkyl esters, evaluated at pH 7.5 and 30 °C, vary...
| Main Authors: | , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier,
2017-10-31T14:29:01Z.
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| Subjects: | |
| Online Access: | Get fulltext |