Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

Fever is a universal response to infection, and opportunistic pathogens such as Candida albicans have evolved complex circuitry to sense and respond to heat. Here we harness RNA-seq and ChIP-seq to discover that the heat shock transcription factor, Hsf1, binds distinct motifs in nucleosome-depleted...

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Bibliographic Details
Main Authors: Leach, Michelle D. (Author), Tan, Kaeling (Author), Miao, Zhengqiang (Author), Walker, Louise A. (Author), Cuomo, Christina A. (Author), Wheeler, Robert T. (Author), Brown, Alistair J. P. (Author), Wong, Koon Ho (Author), Cowen, Leah E. (Author), Farrer, Rhys (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-09-18T15:38:54Z.
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