Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules

Dengue Virus-Infected Dendritic Cells, but Not Monocytes, Activate Natural Killer Cells through a Contact-Dependent Mechanism Involving Adhesion Molecules

Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the ea...

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Bibliographic Details
Main Authors: Costa, Vivian Vasconcelos (Author), Ye, Weijian (Author), Chen, Qingfeng (Author), Teixeira, Mauro Martins (Author), Preiser, Peter (Author), Ooi, Eng Eong (Author), Chen, Jianzhu (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Society for Microbiology, 2017-08-18T13:48:38Z.
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