Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth

The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be effective in endometrial cancer. Recently it has been shown that hormone-bindin...

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Main Authors: Holst, Frederik (Author), Hoivik, Erling A. (Author), Taylor-Weiner, Amaro (Author), Schumacher, Steven E. (Author), Asmann, Yan W. (Author), Grossmann, Patrick (Author), Trovik, Jone (Author), Necela, Brian M. (Author), Thompson, E. Aubrey (Author), Salvesen, Helga B. (Author), Cherniack, Andrew D. (Author), Gibson, William J (Contributor), Beroukhim, Rameen (Contributor), Meyerson, Matthew L. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Broad Institute of MIT and Harvard (Contributor), Harvard University- (Contributor), Meyerson, Matthew L (Contributor)
Format: Article
Language:English
Published: Nature Publiashing Group, 2017-06-29T18:58:34Z.
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