Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression

The angiogenic switch, the time at which a tumor becomes vascularized, is a critical step in tumor progression. Indeed, without blood supply, tumors will fail to grow beyond 1mm[superscript 3] and are unlikely to disseminate. The extracellular matrix (ECM), a major component of the tumor microenviro...

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Bibliographic Details
Main Authors: Clauser, Karl R. (Author), Mani, D. R. (Author), Carr, Steven A. (Author), Naba, Alexandra (Contributor), Hynes, Richard O. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-06-21T13:49:59Z.
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