Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

Activation of cellular stress response pathways to maintain metabolic homeostasis is emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of pancreatic ductal adenocarcinoma (PDA) requires high levels of autophagy a conserved self-degradative process. However, the r...

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Main Authors: Perera, Rushika M. (Author), Stoykova, Svetlana (Author), Nicolay, Brandon N. (Author), Ross, Kenneth N. (Author), Fitamant, Julien (Author), Boukhali, Myriam (Author), Lengrand, Justine (Author), Deshpande, Vikram (Author), Selig, Martin K. (Author), Ferrone, Cristina R. (Author), Settleman, Jeff (Author), Stephanopoulos, Gregory (Contributor), Dyson, Nicholas J. (Author), Zoncu, Roberto (Author), Ramaswamy, Sridhar (Author), Haas, Wilhelm (Author), Bardeesy, Nabeel (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-06-08T17:51:04Z.
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