Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...

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Main Authors: Hu, Joyce K. (Author), Crampton, Jordan (Author), Sanders, Rogier W. (Author), Moore, John P. (Author), Crotty, Shane (Author), Tam, Hok Hei (Contributor), Melo, Mariane Bandeira (Contributor), Kang, Myung Sun (Contributor), Pelet, Jeisa (Contributor), Ruda, Vera (Contributor), Foley, Maria Hottelet (Contributor), Kumari, Sudha (Contributor), Baldeon, Alexis D (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor), Chakraborty, Arup K (Contributor), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2017-05-09T19:03:11Z.
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