TET1 is a tumor suppressor of hematopoietic malignancy

TET1 is a tumor suppressor of hematopoietic malignancy

The methylcytosine dioxygenase TET1 ('ten-eleven translocation 1') is an important regulator of 5-hydroxymethylcytosine (5hmC) in embryonic stem cells. The diminished expression of TET proteins and loss of 5hmC in many tumors suggests a critical role for the maintenance of this epigenetic...

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Main Authors: Cimmino, Luisa (Author), Ndiaye-Lobry, Delphine (Author), Yap, Yoon Sing (Author), Bakogianni, Sofia (Author), Yu, Yiting (Author), Bhattacharyya, Sanchari (Author), Shaknovich, Rita (Author), Geng, Huimin (Author), Lobry, Camille (Author), Mullenders, Jasper (Author), King, Bryan (Author), Trimarchi, Thomas (Author), Aranda-Orgilles, Beatriz (Author), Liu, Cynthia (Author), Shen, Steven (Author), Verma, Amit K (Author), Aifantis, Iannis (Author), Dawlaty, Meelad M (Contributor), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-04-20T18:20:00Z.
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