HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

Broadly neutralizing antibodies (bnAbs) against the N332 supersite of the HIV envelope (Env) trimer are the most common bnAbs induced during infection, making them promising leads for vaccine design. Wild-type Env glycoproteins lack detectable affinity for supersite-bnAb germline precursors and are...

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Main Authors: Steichen, Jon M (Author), Kulp, Daniel W (Author), Escolano, Amelia (Author), Dosenovic, Pia (Author), Stanfield, Robyn L (Author), McCoy, Laura E (Author), Ozorowski, Gabriel (Author), Hu, Xiaozhen (Author), Kalyuzhniy, Oleksandr (Author), Briney, Bryan (Author), Schiffner, Torben (Author), Garces, Fernando (Author), Freund, Natalia T (Author), Gitlin, Alexander D (Author), Menis, Sergey (Author), Georgeson, Erik (Author), Kubitz, Michael (Author), Adachi, Yumiko (Author), Jones, Meaghan (Author), Mayer, Christian T (Author), Ward, Andrew B (Author), Burton, Dennis R (Author), Wilson, Ian A (Author), Irvine, Darrell J (Author), Nussenzweig, Michel C (Author), Schief, William R (Author), Tokatlian, Talar (Contributor), Mutafyan, Andrew Ayk (Contributor), Yun, Dong Soo (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-13T19:47:23Z.
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