Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

Tumor cells disseminate into compartments that are poorly accessible from circulation, which necessitates high doses of systemic chemotherapy. However, the effectiveness of many drugs, such as the potent topoisomerase I poison SN-38, is hampered by poor pharmacokinetics. To deliver SN-38 to lymphoma...

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Main Authors: Abraham, Wuhbet (Contributor), Zheng, Yiran (Contributor), Huang, Bonnie (Contributor), Bustamante Lopez, Sandra C (Contributor), Irvine, Darrell J (Contributor), Luo, Samantha (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Luo, Samantha S. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-04-13T16:16:00Z.
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