Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells
Recall responses by memory CD8 T cells are impaired in the absence of CD4 T cells. Although several mechanisms have been proposed, the molecular basis is still largely unknown. Using a local influenza virus infection in the respiratory tract and the lung of CD4[superscript −/−] mice, we show that me...
| Main Authors: | , , , , , |
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| Other Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
American Association of Immunologists,
2017-04-06T15:43:11Z.
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| Subjects: | |
| Online Access: | Get fulltext |