Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

Ionizable Amphiphilic Dendrimer-Based Nanomaterials with Alkyl-Chain-Substituted Amines for Tunable siRNA Delivery to the Liver Endothelium In Vivo

A library of dendrimers was synthesized and optimized for targeted small interfering RNA (siRNA) delivery to different cell subpopulations within the liver. Using a combinatorial approach, a library of these nanoparticle-forming materials was produced wherein the free amines on multigenerational pol...

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Main Authors: Khan, Omar Fizal (Contributor), Zaia, Edmond (Contributor), Yin, Hao (Contributor), Bogorad, Roman (Contributor), Pelet, Jeisa (Contributor), Webber, Matthew (Contributor), Zhuang, Iris (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor), Dahlman, James E. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dahlman, James (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2017-03-06T21:03:36Z.
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