SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7

SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7

Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blo...

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Main Authors: Guo, H. (Author), Zhang, J. (Author), Zhang, X. (Author), Wang, Y. (Author), Yu, H. (Author), Yin, X. (Author), Li, J. (Author), Du, P. (Author), Plumas, J. (Author), Chaperot, L. (Author), Su, L. (Author), Liu, Y. (Author), Zhang, L. (Author), Chen, Jianzhu (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association of Immunologists, 2017-01-10T14:52:34Z.
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