Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting possible additional...

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Bibliographic Details
Main Authors: Teng, Xin (Author), Liu, Ling (Author), Looper, Ryan E. (Author), Rabinowitz, Joshua D. (Author), Vander Heiden, Matthew G. (Contributor), Mattaini, Katherine Ruth (Contributor), Fan, Jing,M. Eng.Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2016-12-15T14:42:06Z.
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