Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody epitopes that elicit weak humoral responses may not be accessible by conventional B cell panning methods. To demonstrate an alternative strategy to...

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Main Authors: Tharakaraman, Kannan (Author), Rowley, Kirk J (Author), Costa, Vivian V (Author), Chan, Kuan Rong (Author), Wong, Yee Hwa (Author), Ong, Li Ching (Author), Tan, Hwee Cheng (Author), Koch, Tyree (Author), Viswanathan, Karthik (Author), Liew, Chong Wai (Author), Tissire, Hamid (Author), Ramakrishnan, Boopathy (Author), Myette, James R (Author), Babcock, Gregory J (Author), Alonso, Sylvie (Author), Lescar, Julien (Author), Shriver, Zachary (Author), Ooi, Eng Eong (Author), Robinson, Luke Nathaniel (Contributor), Kirloskar, Rama Sanjay (Contributor), Sasisekharan, Viswanathan (Contributor), Chen, Jianzhu (Contributor), Sasisekharan, Ram (Contributor), Cain, David (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Cain, David Joseph (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-11-08T19:17:41Z.
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