Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin

Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin

The monofunctional platinum anticancer agent phenanthriplatin generates covalent adducts with the purine bases guanine and adenine. Preferential nucleotide binding was investigated by using a polymerase stop assay and linear DNA amplification with a 163-base pair DNA double helix. Similarly to cispl...

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Bibliographic Details
Main Authors: Riddell, Imogen Anne (Contributor), Johnstone, Timothy (Contributor), Park, Ga Young (Contributor), Lippard, Stephen J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: John Wiley & Sons, 2016-08-25T18:55:42Z.
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