Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C[subscript 1]

A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C1 is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis (CM). Specifically, we illustrate that catalyst-co...

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Bibliographic Details
Main Authors: Speed, Alexander W. H. (Author), Mann, Tyler J. (Author), O'Brien, Robert V. (Author), Schrock, Richard Royce (Contributor), Hoveyda, Amir H. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2016-08-25T16:02:08Z.
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