Catalytic Z-Selective Cross-Metathesis in Complex Molecule Synthesis: A Convergent Stereoselective Route to Disorazole C[subscript 1]
A convergent diastereo- and enantioselective total synthesis of anticancer and antifungal macrocyclic natural product disorazole C1 is reported. The central feature of the successful route is the application of catalytic Z-selective cross-metathesis (CM). Specifically, we illustrate that catalyst-co...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2016-08-25T16:02:08Z.
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Subjects: | |
Online Access: | Get fulltext |