SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

Defects in DNA repair have been linked to cognitive decline with age and neurodegenerative disease, yet the mechanisms that protect neurons from genotoxic stress remain largely obscure. We sought to characterize the roles of the NAD[superscript +]-dependent deacetylase SIRT1 in the neuronal response...

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Main Authors: Dobbin, Matthew M. (Contributor), Madabhushi, Ram (Contributor), Pan, Ling (Contributor), Chen, Yue (Author), Kim, Dohoon (Author), Gao, Jun (Author), Ahanonu, Biafra (Contributor), Pao, Ping-Chieh (Contributor), Qiu, Yi (Author), Zhao, Yingming (Author), Tsai, Li-Huei (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-05-24T23:01:16Z.
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