In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

Probing gene function in the mammalian brain can be greatly assisted with methods to manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) can be used to edit single or mu...

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Main Authors: Swiech, Lukasz (Contributor), Heidenreich, Matthias (Contributor), Banerjee, Abhishek (Contributor), Habib, Naomi (Contributor), Li, Yinqing (Contributor), Trombetta, John (Author), Sur, Mriganka (Contributor), Zhang, Feng (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-05-18T18:03:09Z.
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