Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice

Disruptions in circadian rhythms and dopaminergic activity are involved in the pathophysiology of bipolar disorder, though their interaction remains unclear. Moreover, a lack of animal models that display spontaneous cycling between mood states has hindered our mechanistic understanding of mood swit...

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Main Authors: Sidor, M. M. (Author), Spencer, S. M. (Author), Dzirasa, K. (Author), Parekh, P. K. (Author), Tye, Kay (Contributor), Warden, M. R. (Author), Arey, R. N. (Author), Enwright, J. F. (Author), Jacobsen, J. P. R. (Author), Kumar, S. (Author), Remillard, E. M. (Author), Caron, M. G. (Author), Deisseroth, K. (Author), McClung, C. A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-05-18T14:39:02Z.
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