Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were induced by hypoxia in a hypoxia-inducible factor-1α (HIF-1α)-de...

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Bibliographic Details
Main Authors: Bensaad, Karim (Author), Favaro, Elena (Author), Lewis, Caroline A (Author), Peck, Barrie (Author), Lord, Simon (Author), Collins, Jennifer M (Author), Pinnick, Katherine E (Author), Wigfield, Simon (Author), Buffa, Francesca M (Author), Li, Ji-Liang (Author), Zhang, Qifeng (Author), Wakelam, Michael J.O (Author), Karpe, Fredrik (Author), Schulze, Almut (Author), Harris, Adrian L (Author), Lewis, Caroline (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor), Lewis, Caroline A. (Contributor)
Format: Article
Language:English
Published: 2016-03-07T16:54:14Z.
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