Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetr...

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Main Authors: Fedeles, Bogdan I. (Contributor), Freudenthal, Bret D. (Author), Yau, Emily (Contributor), Singh, Vipender (Contributor), Chang, Shiou-chi (Contributor), Li, Deyu (Contributor), Delaney, James C. (Contributor), Wilson, Samuel H. (Author), Essigmann, John M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2016-03-02T16:51:06Z.
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