Structure-Based Redesign of the Binding Specificity of Anti-Apoptotic Bcl-x[subscript L]

Many native proteins are multi-specific and interact with numerous partners, which can confound analysis of their functions. Protein design provides a potential route to generating synthetic variants of native proteins with more selective binding profiles. Redesigned proteins could be used as resear...

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Bibliographic Details
Main Authors: Chen, T. Scott (Contributor), Palacios, Hector (Contributor), Keating, Amy E. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-25T03:18:14Z.
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