Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

Phenotyping single cells based on the products they secrete or consume is a key bottleneck in many biotechnology applications, such as combinatorial metabolic engineering for the overproduction of secreted metabolites. Here we present a flexible high-throughput approach that uses microfluidics to co...

Full description

Bibliographic Details
Main Authors: Ghaderi, Adel (Contributor), Zhou, Hang (Contributor), Agresti, Jeremy (Author), Stephanopoulos, Gregory (Contributor), Wang, Benjamin L. (Contributor), Weitz, David A. (Author), Fink, Gerald R (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Whitehead Institute for Biomedical Research (Contributor), Fink, Gerald R. (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-02-23T00:42:50Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items