In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation

Hypoxic and VHL-deficient cells use glutamine to generate citrate and lipids through reductive carboxylation (RC) of α-ketoglutarate. To gain insights into the role of HIF and the molecular mechanisms underlying RC, we took advantage of a panel of disease-associated VHL mutants and showed that HIF e...

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Bibliographic Details
Main Authors: Gameiro, Paulo A (Author), Yang, Juanjuan (Author), Metelo, Ana M (Author), Baker, Rania (Author), Wang, Zongwei (Author), Arreola, Alexandra (Author), Rathmell, W. Kimryn (Author), Olumi, Aria F. (Author), Stephanopoulos, Gregory (Contributor), Iliopoulos, Othon (Author), Perez-Carro, Rocio (Author), Lopez-Larrubia, Pilar (Author), Gameiro, Paulo A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-23T00:34:12Z.
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