EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

EGFR Variant Heterogeneity in Glioblastoma Resolved through Single-Nucleus Sequencing

Glioblastomas (GBM) with EGFR amplification represent approximately 50% of newly diagnosed cases, and recent studies have revealed frequent coexistence of multiple EGFR aberrations within the same tumor, which has implications for mutation cooperation and treatment resistance. However, bulk tumor se...

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Main Authors: Francis, Joshua M. (Author), Zhang, Cheng-Zhong (Author), Maire, Cecile L. (Author), Jung, Joonil (Author), Manzo, Veronica E. (Author), Homer, Heather (Author), Haidar, Sam (Author), Blumenstiel, Brendan (Author), Pedamallu, Chandra Sekhar (Author), Ligon, Azra H. (Author), Meyerson, Matthew L. (Author), Ligon, Keith L. (Author), Adalsteinsson, Viktor A. (Author), Love, John C (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Adalsteinsson, Viktor Arnarson (Contributor), Love, J. Christopher (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2016-02-19T01:51:22Z.
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