The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway

T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development and effective immune responses to pathogens and transformed cells while avoiding autoimmunity. The Src family kinase Lck and the Syk family kinase ZAP-70 (ζ chain-associa...

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Main Authors: Sjolin-Goodfellow, Hanna (Author), Frushicheva, Maria P. (Contributor), Ji, Qinqin (Author), Cheng, Debra A. (Author), Kadlecek, Theresa A. (Author), Cantor, Aaron J. (Author), Kuriyan, John (Author), Salomon, Arthur R. (Author), Weiss, Arthur (Author), Chakraborty, Arup K (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Chakraborty, Arup K. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-02-11T03:50:52Z.
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