CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in vivo as well as ex vivo genome editing using adeno-associated virus (AAV)-, le...

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Main Authors: Chen, Sidi (Contributor), Zhou, Yang (Contributor), Yim, Michael J (Author), Swiech, Lukasz (Contributor), Kempton, Hannah R (Author), Dahlman, James E (Author), Parnas, Oren (Author), Eisenhaure, Thomas M (Author), Jovanovic, Marko (Author), Graham, Daniel B (Author), Jhunjhunwala, Siddharth (Contributor), Heidenreich, Matthias (Contributor), Xavier, Ramnik J (Author), Hacohen, Nir (Author), Regev, Aviv (Contributor), Feng, Guoping (Contributor), Sharp, Phillip A. (Contributor), Zhang, Feng (Contributor), Anderson, Daniel Griffith (Contributor), Kempton, Hannah R. (Contributor), Dahlman, James E. (Contributor), Langer, Robert S (Author), Platt, Randall Jeffrey (Author), Yim, Michael (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Platt, Randall (Contributor), Yim, Michael J. (Contributor), Langer, Robert (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-02-09T18:37:24Z.
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