A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial

Abstract Background A subset of COPD-patients presents with eosinophilic airway inflammation. While treatment of asthmatic patients with the GATA3-specific DNAzyme SB010 attenuated sputum eosinophilia after allergen challenge, this specific treatment has not been evaluated in patients with COPD. Our...

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Bibliographic Details
Main Authors: Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier, Henrik Watz
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Respiratory Research
Subjects:
COPD
Sputum
Eosinophils
T-helper-2-cells
DNAzyme
SB010
Online Access:http://link.springer.com/article/10.1186/s12931-018-0751-x

Internet

http://link.springer.com/article/10.1186/s12931-018-0751-x

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