Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption

Protective role of FKBP51 in calcium entry-induced endothelial barrier disruption

Pulmonary artery endothelial cells (PAECs) express a cation current, I SOC (store-operated calcium entry current), which when activated permits calcium entry leading to inter-endothelial cell gap formation. The large molecular weight immunophilin FKBP51 inhibits I SOC but not other calcium entry pat...

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Bibliographic Details
Main Authors: Caleb L. Hamilton, Pierre I. Kadeba, Audrey A. Vasauskas, Viktoriya Solodushko, Anna K. McClinton, Mikhail Alexeyev, Jonathan G. Scammell, Donna L. Cioffi
Format: Article
Language:English
Published: SAGE Publishing 2018-01-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045893217749987

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