Regulation of the Escherichia coli HipBA toxin-antitoxin system by proteolysis.

Bacterial populations produce antibiotic-tolerant persister cells. A number of recent studies point to the involvement of toxin/antitoxin (TA) modules in persister formation. hipBA is a type II TA module that codes for the HipB antitoxin and the HipA toxin. HipA is an EF-Tu kinase, which causes prot...

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Bibliographic Details
Main Authors: Sonja Hansen, Marin Vulić, Jungki Min, Tien-Jui Yen, Maria A Schumacher, Richard G Brennan, Kim Lewis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3376134?pdf=render