Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells

Abstract Background Prostate cancer is one of the most commonly diagnosed cancers in men worldwide. Currently available therapies for metastatic prostate cancer are only marginally effective. Therefore, new therapeutic agents are urgently needed to improve patient outcome. Isoalantolactone (IATL), a...

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Bibliographic Details
Main Authors: Wei Chen, Ping Li, Yi Liu, Yu Yang, Xueting Ye, Fangyi Zhang, Hang Huang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Reactive oxygen species
Isoalantolactone
ER stress
STAT3
Prostate cancer
Online Access:http://link.springer.com/article/10.1186/s13046-018-0987-9

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http://link.springer.com/article/10.1186/s13046-018-0987-9

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