Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-<i>b</i>]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors

Synthesis, Characterization, and Biological Activity of a Novel Series of Benzo[4,5]imidazo[2,1-<i>b</i>]thiazole Derivatives as Potential Epidermal Growth Factor Receptor Inhibitors

Based on the analysis of epidermal growth factor receptor (EGFR) complexes with gefitinib with molecular docking, the scaffold-hopping strategy, combination of the active substructures, and structural optimization of EGFR inhibitors, a novel series of benzo[4,5]imidazo[2,1-<i>b</i>]thiaz...

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Bibliographic Details
Main Authors: Xinshan Deng, Xiaoyu Tan, Tiantian An, Qingqing Ma, Zhe Jin, Ce Wang, Qingguo Meng, Chun Hu
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
EGFR inhibitors
heterocycle
synthesis
molecular docking
antitumor activity
Online Access:https://www.mdpi.com/1420-3049/24/4/682

Internet

https://www.mdpi.com/1420-3049/24/4/682

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