Foam Cell Induction Activates AMPK but Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis

Foam Cell Induction Activates AMPK but Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis

The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and plays essential roles regulating macrophage lipid dynamics. Here, we investigated the consequences of atherogenic lipoprotein-induced foam cel...

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Bibliographic Details
Main Authors: Nicholas D. LeBlond, Julia R. C. Nunes, Tyler K. T. Smith, Conor O’Dwyer, Sabrina Robichaud, Suresh Gadde, Marceline Côté, Bruce E. Kemp, Mireille Ouimet, Morgan D. Fullerton
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
macrophage
AMP-activated protein kinase (AMPK)
autophagy
immunometabolism
lysosomal homeostasis
atherosclerosis
Online Access:https://www.mdpi.com/1422-0067/21/23/9033

Internet

https://www.mdpi.com/1422-0067/21/23/9033

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