IL-35 and RANKL Synergistically Induce Osteoclastogenesis in RAW264 Mouse Monocytic Cells

IL-35 and RANKL Synergistically Induce Osteoclastogenesis in RAW264 Mouse Monocytic Cells

Interleukin (IL)-35 is an immunosuppressive cytokine mainly produced by regulatory T cells. IL-35 mediates immunological functions by suppressing the inflammatory immune response. However, the role of IL-35 in bone-destructive diseases remains unclear, especially in terms of osteoclastogenesis. Ther...

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Bibliographic Details
Main Authors: Yosuke Kamiya, Takeshi Kikuchi, Hisashi Goto, Iichiro Okabe, Yuhei Takayanagi, Yuki Suzuki, Noritaka Sawada, Teppei Okabe, Shun Kondo, Jun-ichiro Hayashi, Akio Mitani
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin-35
osteoimmunology
inflammatory bone destruction
Online Access:https://www.mdpi.com/1422-0067/21/6/2069

Internet

https://www.mdpi.com/1422-0067/21/6/2069

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