Simultaneous and stoichiometric purification of hundreds of oligonucleotides

Chemically synthesized DNA oligonucleotides (oligos) require purification to remove truncated species. Here, the authors developed a high-throughput method for oligo purification that also normalises the concentrations of the oligos in the final samples.

Bibliographic Details
Main Authors: Alessandro Pinto, Sherry X. Chen, David Yu Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04870-w