Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action

Thioridazine: A Non-Antibiotic Drug Highly Effective, in Combination with First Line Anti-Tuberculosis Drugs, against Any Form of Antibiotic Resistance of Mycobacterium tuberculosis Due to Its Multi-Mechanisms of Action

This review presents the evidence that supports the use of thioridazine (TZ) for the therapy of a pulmonary tuberculosis infection regardless of its antibiotic resistance status. The evidence consists of in vitro and ex vivo assays that demonstrate the activity of TZ against all encountered Mycobact...

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Bibliographic Details
Main Authors: Leonard Amaral, Miguel Viveiros
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:Antibiotics
Subjects:
antibiotic resistant pulmonary tuberculosis
thioridazine
in vitro activity
ex vivo activity
in vivo activity (murine model and human trails)
the non-killing macrophage
enhancement of intracellular killing of Mtb by thioridazine
mechanism of actions of thioridazine
Online Access:http://www.mdpi.com/2079-6382/6/1/3

Internet

http://www.mdpi.com/2079-6382/6/1/3

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