Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii

Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii

Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes of the transsulfuration and...

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Bibliographic Details
Main Authors: Elena Maresi, Giacomo Janson, Silvia Fruncillo, Alessandro Paiardini, Rosario Vallone, Paola Dominici, Alessandra Astegno
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
Toxoplasma gondii
cystathionine γ-lyase
pyridoxal-5′-phosphate
reverse transsulfuration pathway
reaction specificity
Online Access:http://www.mdpi.com/1422-0067/19/7/2111

Internet

http://www.mdpi.com/1422-0067/19/7/2111

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