Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

Nicotinic acetylcholine receptor signaling regulates inositol‐requiring enzyme 1α activation to protect β‐cells against terminal unfolded protein response under irremediable endoplasmic reticulum stress

Abstract Aims/Introduction Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol‐requiring enzyme 1α (IRE1α) triggers the terminal unfolded protein response (T‐UPR), causing crucial cell dysfunction and apoptosis. We hypothesized that nicotinic acetylcholine receptor (nAChR)...

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Bibliographic Details
Main Authors: Tatsuya Ishibashi, Shuhei Morita, Shohei Kishimoto, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hidefumi Inaba, Hiroyuki Ariyasu, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Feroz R Papa, Takashi Akamizu
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Journal of Diabetes Investigation
Subjects:
Inositol‐requiring enzyme 1α
Nicotinic acetylcholine receptor
Pancreatic β cell
Online Access:https://doi.org/10.1111/jdi.13211

Internet

https://doi.org/10.1111/jdi.13211

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