FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

Osteoinductive bone morphogenetic proteins (BMPs), including BMP-2, have a unique capability of mediating bone formation both in orthotopic and ectopic locations. Immunosuppresive macrolides have been shown to potentiate BMP-2 activity through FKBP12, but these have yet to translate to effective ost...

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Bibliographic Details
Main Authors: Sreedhara Sangadala, Emily J. Devereaux, Steven M. Presciutti, Scott D. Boden, Nick J. Willet
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
BMP-2
tacrolimus
osteogenesis
small molecule
Online Access:https://www.mdpi.com/1422-0067/20/8/1900

Internet

https://www.mdpi.com/1422-0067/20/8/1900

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